4. Toxicity profiles assessed by NCI-CTCAE version 3.0.

Grade	0	1	2	3	4	0	1	2	3	4	0	1	2	3	4	0	1	2	3	4
NCI-CTCAE, National Cancer Institute Common Terminology Criteria for Adverse Events; DL, dose level; DL-1 was 30 mg/m2, DL-2 was 40 mg/m2, DL-3 was 50 mg/m2, and DL-4 was 60 mg/m2. *, the same patient.
Hematological toxicity	Leukopenia					Neutropenia					Anemia					Thrombocytopenia
DL1	3	0	0	0	0	3	0	0	0	0	1	2	0	0	0	3	0	0	0	0
DL2	2	1	0	0	3	0	2	0	0	3	1	0	1	0	5	0	0	0	0
DL3	2	0	2	1	1	1	2	1	2	0	1	2	1	2	0	6	0	0	0	0
DL4	0	0	1	1	1	0	0	2	0	1	0	0	1	2	0	3	0	0	0	0
Non-hematological toxicity	Diarrhea					Nausea/Vomiting					Asthenia					Ileus
DL1	3	0	0	0	0	3	0	0	0	0	1	2	0	0	0	3	0	0	0	0
DL2	2	2	1	0	0	4	0	1	0	0	5	0	0	0	0	4	1	0	0	0
DL3	0	3	2	1*	0	2	1	1	1*	0	5	0	1	0	0	6	0	0	0	0
DL4	0	0	2	1*	0	3	0	0	0	0	1	2	0	0	0	2	0	1	0	0
Non-hematological toxicity	Abdominal pain					Liver dysfunction					Renal dysfunction					Hypersensitivity
DL1	3	0	0	0	0	2	1	0	0	0	3	0	0	0	0	3	0	0	0	0
DL2	5	0	0	0	0	3	2	0	0	0	5	0	0	0	0	5	0	0	0	0
DL3	3	2	0	1*	0	3	3	0	0	0	6	0	0	0	0	6	0	0	0	0
DL4	1	0	1	1*	0	3	0	0	0	0	3	0	0	0	0	3	0	0	0	0