7. CBR, PFS and OS with or without deleterious gBRCA mutations according to type of chemotherapy .
Results | PBCT (n=44) | NPCT (n=70) | |||||
With (n=7) | Without (n=37) | P | With (n=7) | Without (n=63) | P | ||
CBR, clinical benefit rate; PFS, progression-free survival; OS, overall survival; gBRCA, germline BRCA1/2; PBCT, platinum-based chemotherapy; NPCT, non-platinum-based chemotherapy; 95% CI, 95% confidence interval. | |||||||
CBR | 85.7% (6/7) | 35.1% (13/37) | 0.039 | 57.1% (4/7) | 39.7% (25/63) | 0.627 | |
PFS [median (95% CI)] (month) | 14.9 (6.9−22.9) | 5.3 (4.0−6.6) | 0.001 | 5.8 (1.2−10.4) | 5.1 (3.8−6.4) | 0.677 | |
OS [median (95% CI)] (month) | 26.5 (−) | 15.5 (10.9−20.2) | 0.161 | − | 14.5 (10.4−18.6) | 0.075 |