Table 1:
Properties of different excipients examined for use in the twin-screw granulation process.
| S.No | Trade Name | Chemical Name | Category | Tg/MP (°C) | Molecular Weight (Dalton) | Reference |
|---|---|---|---|---|---|---|
| 1. | Klucel™ EF | Hydroxy propyl cellulose | Binder | 120/NA* | 80,000 | (VR Kallakunta et al., 2018) |
| 2. | Kollidon® VA64 | Vinylpyrrolidone-Vinyl acetate co-polymer. | Binder | 101/NA | 45,000–70,000 | |
| 3. | Aqualon™ T10 | Ethyl cellulose | Sustained release agent | 150–156/NA | 75,000 | |
| 4. | Neusilin® (US2) | Magnesium aluminometasilicate | Carrier | >300/ NA | 262.43 | (Majumder et al., 2018) |
| 5. | Affinisol™ HPMC HME 100LV | Hydroxy propyl methyl cellulose | Polymeric Binder | 111/NA | 180,000 | (Liu et al., 2017) |
| 6. | Affinisol™ HPMC HME 4M | Hydroxy propyl methyl cellulose | Polymeric Binder | 111/NA | 550,000 | |
| 7. | Klucel™ HF | Hydroxy propyl cellulose | Sustained release agent | NA/>170 | 1,150,000 | (Upadhye et al., 2017) |
| 8. | Natrasol™ 250 L | Hydroxy ethyl cellulose | Sustained release agent | NA/NA | 90,000 | |
| 9. | Ethocel standard 10 | Ethyl cellulose | Sustained release agent | 129–133/165–173 | NA | |
| 10. | PEG 2000 | Polyethylene glycol 2000 | Binder | NA/49–52 | 1800 | (Maniruzzaman et al., 2015) |
| 11. | Compritol 888 ATO | Glyceryl behenate | Lipid binder | NA/69–74 | 414.7 | (Keen et al., 2015) |
| 12. | PEG 4000 | Polyethylene glycol 4000 | Binder | NA/53 | 3600–4400 | (T Monteyne et al., 2016) |
| 13. | Soluplus | Polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol | Binder | 70/NA | 90,000–140,000 | |
| 14. | Hydroxy propyl cellulose SSL | Hydroxypropyl cellulose | Sustained release agent | NA/180–220 | 40,000 | (Venkata Kallakunta et al., 2018) |
| 15. | Stearic acid | Octadecanoic acid | Binder | NA/69.3 | 284.48 | (Patil et al., 2015) |
| 16. | Kollidon 12 PF | Polyvinylpyrrolidone | Polymeric Binder | 72/NA | 2000–3000 | (Batra et al., 2016) |
| 17. | Kollidon 30 | Polyvinylpyrrolidone | Polymeric Binder | 160/NA | 44,000–54,000 | |
| 18. | Klucel JXF | Hydroxypropyl cellulose | Polymeric Binder | ~19/~200 | ~140,000 | |
| 19. | Affinisol 6cP | Hydroxypropyl methylcellulose | Polymeric Binder | 95/NA | NA | |
| 20. | Aqoat® LG | Hydroxypropyl methylcellulose acetate succinate | Polymeric Binder | 122/NA | 17,000–2000 | |
| 21. | HPMC Phthalate HP 55 | Hydroxypropyl methylcellulose phthalate | Polymeric Binder | 145/NA | 45,600 | |
| 22. | Eudragit EPO | Poly (butyl methacrylate-codimeth laminoethyl methacrylate-comethyl methacrylate) (1:2:1) | Polymeric Binder | 45/NA | 47,000 | |
| 23. | Eudragit L100–55 | Poly (methacrylic acid-co-ethyl acrylate) (1:1) | Polymeric Binder | 110/NA | 32000 | |
| 24. | Lutrol micro F127 | Poloxamer | Polymeric Binder | NA/52 | 9840–14600 | |
| 25. | Kolliphor P188 | Poloxamer | Polymeric Binder | NA/52 | 7680–9510 | |
| 26. | Polyox N10 NF | Polyethylene oxide | Polymeric Binder | NA/68 | 100,000 | |
| 27. | SentryPolyox® WSR N12K | Polyethylene oxide | Sustained release agent | NA/68 | 1,000,000 | (Tinne Monteyne et al., 2016) |
*
NA: Not Available