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. 2020 May 7;3(6):e201900545. doi: 10.26508/lsa.201900545

Figure 1. MAPK pathway mutations in head and neck squamous cell carcinoma (HNSCC) are associated with remarkable patient survival.

Figure 1.

(A) Percentage of patients affected by MAPK pathway mutations and mutations of six other cancer pathways (PI3K, JAK/STAT, Notch, WNT, NF-κB, and TGFβ/Smad) in TCGA HNSCC provisional cohort (N = 510). (B) HNSCC patient outcome associations for all seven pathway mutations (i.e., pathway-mutated versus pathway WT) and HPV status. Red bars indicate favorable HNSCC overall survival (OS), whereas the blue bar indicates unfavorable OS when the pathway components are mutated (log-rank test P-values are shown). (C) Kaplan–Meier OS curves for MAPK pathway-mutated HNSCC patients versus MAPK pathway WT patients (TCGA HNSCC provisional cohort). (D) Kaplan–Meier OS curves for TP53-mutated patients with MAPK pathway-mutated versus WT HNSCC (TCGA HNSCC provisional cohort). (E) Bar graph showing the number of MAPK pathway protein components for each cancer type (total 33 cancer types) that were significantly correlated with OS. Red bars indicate associations with favorable outcomes, whereas grey bars indicate associations with unfavorable outcomes in each cancer type, when the MAPK protein component(s) is/are overexpressed (median cutoff; The Cancer Protein Atlas database). (F) Kaplan–Meier OS curves for MAPK pathway-mutated HNSCC patients versus MAPK pathway WT patients (MSK-IMPACT HNSCC cohort). (G) Kaplan–Meier survival curves showing increased OS for uterine corpus endometrial carcinoma patients with MAPK pathway mutation versus WT (TCGA uterine corpus endometrial carcinoma cohort).