Overall survival and the mutational burden of TCGA HNSCC tumors with respective pathway mutations and HPV status. (A, B, C, D, E, F) Kaplan–Meier curves showing overall survival of head and neck squamous cell carcinoma (HNSCC) patients with or without mutations of the remaining six key cancer pathways (PI3K, NOTCH, JAK/STAT, NF-κB, WNT, and TGF-β/Smad pathways) in the HNSCC provisional cohort (N = 508; TCGA). (G) Comparison of mutational loads of HNSCC tumors with all seven HNSCC-relevant cancer signaling pathways mutated, as well as HPV-positive tumors. Unpaired t test P-values are shown.