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Immune-related transcriptome signatures of HPV negative HNSCCS. (A) Bar graphs showing significant increase in expression levels of PRF1, GZMA, GZMB, GZMK, GZMH, and GZMM in HPV-negative MAPK-mutated versus MAPK-WT HNSCC tumors (TCGA Provisional cohort). (B) Clustering of tumor infiltrating immune cell types and immune signature scores (CYT, T-effector signature and IFN-γ functionality score) in TCGA HPV-negative HNSCC tumors with MAPK pathway mutational status.
