Table 2.

Multivariable adjusted^a associations of hormone levels with all-cause and cause-specific mortality: men (n = 1006).

All-cause mortality (events = 128)	SHBG	TT	cFT	DHT
	1.24 (1.00, 1.54)	0.87 (0.77, 0.98)	0.85 (0.73, 0.97)	0.89 (0.77, 1.03)
CVD – mortality (events = 60)	SHBG	TT	cFT	DHT
	1.23 (0.88, 1.72)	0.90 (0.70, 1.17)	0.85 (0.65, 1.12)	0.93 (0.70, 1.24)
Cancer – mortality (events = 34)	SHBG	TT	cFT	DHT
	1.29 (0.84, 1.97)	0.85 (0.69, 1.04)	0.84 (0.67, 1.06)	0.90 (0.71, 1.13)
Other disease – mortality (events = 34)	SHBG	TT	cFT	DHT
	1.32 (0.89, 1.96)	0.87 (0.71, 1.05)	0.84 (0.65, 1.09)	0.88 (0.67, 1.15)

Data are reported as hazard ratios (95% CI) per 1 logarithmic s.d. increase with P < 0.05 marked as bold; n, sample size.

^aAdjusted for age, batch, systolic blood pressure, LDL cholesterol, use of lipid lowering medication, smoking status, use of antihypertensive medication, prevalent diabetes, BMI, education years, physical activity, alcohol consumption, estimated glomerular filtration rate, high-sensitivity C-reactive protein concentration, prevalent cancer, prevalent myocardial infarction and prevalent stroke. Additionally, SHBG is adjusted for TT and E2; DHT and TT are adjusted for SHBG.

cFT, calculated free testosterone; DHT, dihydrotestosterone; E2, estradiol; SHBG, sex hormone-binding globulin; TT, total testosterone.