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. 2020 Apr 5;9(1):1743036. doi: 10.1080/2162402X.2020.1743036

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© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — In vivo killing of radioresistant cancer cells using the UniCAR system. Cal33 RR^mCherry and UniCAR T cells were mixed at an E:T ratio of 1:1 together with muCD98 TM or EGFR TM and subsequently injected s.c. into the right hind leg of NMRI^nu/nu mice. As a control, Cal33 RR^mCherry cells alone or together with UniCAR T cells were administered. Over a period of 3 days, optical imaging was performed to follow tumor growth based on the mCherry signal. Each group consisted of five mice. Results from one experiment are shown. (a) Each image was scaled to maximum intensity. (b) Quantitative analysis of the mCherry signal. Values were normalized to control group (Cal33 RR^mCherry only) at day 0. (*p < .0332, **p < .0021, ***p < .0002 compared to the control group receiving tumor and UniCAR T cells; One-way ANOVA with post hoc Sidak multiple comparison test).