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. 2020 May 13;23(6):101160. doi: 10.1016/j.isci.2020.101160

Figure 3.

Figure 3

Comparison and Mutation of the Key Residues for the Binding of SARS-CoV-2-S RBD and DPP4

(A) Sequence comparison of the key residues between SARS-CoV-2-S and SARS-CoV-S RBDs. There are an insertion and adjacent substitutions at E484, and a Q498Y substitution in SARS-CoV-2-S RBD.

(B) Effect of mutation at the key residues on the binding free energy. Virtual mutations of single key residues could impact the free energy, especially for D405A and E484A. WT, wild-type.

(C) Comparison of the key residues between human and pangolin DPP4 protein sequences. Both shared the completely identical key residues including K267, L294, I295, R317, R336, and Q344.