Skip to main content
. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Mol Cancer Res. 2019 Dec 20;18(4):574–584. doi: 10.1158/1541-7786.MCR-19-0657

Figure 1: Genomic and proteomic analysis of MGA in lung adenocarcinomas.

Figure 1:

A. Mutation profile of MGA in lung adenocarcinomas. Missense (green dots) and truncating mutations (black dots) are highlighted.

B. Immunoprecipitation-mass spectrometry (IP-Mass Spec) results in HEK293T cells (2 biological replicates). We identified proteins that are significantly enriched by the endogenous MGA antibody, relative to IgG control (adjusted P value < 0.05). The proteins that are part of a noncanonical PRC1 (ncPRC1) – the PCGF6-PRC1 complex – are highlighted by red dots.

C. Immunoprecipitation (IP) of MGA and IgG, followed by immunoblotting of MGA-interacting proteins in HEK293T, A549 and NCI-H23 cells.