Table 3.
Quality of life outcomes and compliance in overall population
| Quality of life and compliance | LMWH (n=948) | LMWH+GCS (n=940) | Mean difference (95% CI)† | P value |
|---|---|---|---|---|
| Received surgery (LMWH n=937, LMWH+GCS n=921) | ||||
| EQ-5D-5L (No; mean (SD)) | ||||
| Baseline | 933; 0.825 (0.185) | 910; 0.818 (0.192) | — | — |
| 1 week or discharge | 874; 0.648 (0.232) | 839; 0.627 (0.244) | 0.015 (−0.004 to 0.033) | 0.12 |
| 14-21 days | 846; 0.788 (0.202) | 820; 0.773 (0.206) | 0.011 (−0.008 to 0.030) | 0.25 |
| 90 days | 774; 0.856 (0.192) | 743; 0.843 (0.197) | 0.011 (−0.009 to 0.031) | 0.27 |
| EQ-5D VAS (No; mean (SD)) | ||||
| Baseline | 932; 77.0 (17.4) | 907; 77.0 (18.2) | — | — |
| 1 week or discharge | 873; 68.2 (19.5) | 837; 67.8 (20.1) | 0.23 (−1.32 to 1.79) | 0.77 |
| 14-21 days | 846; 77.4 (17.4) | 819; 77.2 (17.0) | −0.04 (−1.62 to 1.54) | 0.96 |
| 90 days | 773; 80.2 (17.9) | 743; 80.7 (18.2) | −0.29 (−1.94 to 1.37) | 0.73 |
| Compliance with GCS* (No (%)) | 37 (4.0) | 750 (81.4) | (−0.04 to 0.18) | — |
| Compliance with LMWH (No (%)) | ||||
| Received all prescribed LMWH doses | 768 (82.0) | 755 (82.0) | (−0.81 to 0.19) | — |
| Received ≥50% of prescribed doses | 779 (83.1) | 762 (82.7) | (−0.82 to 0.18) | — |
EQ-5D-5L=EuroQol five dimensions five levels; EQ-5D VAS=EuroQol five dimensions visual analogue scale; GCS=graduated compression stockings; LMWH=low molecular weight heparin.
*
Stockings worn for 75% of total admission time.
†
Non-parametric bounds for average causal effect for compliance outcome.