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. Author manuscript; available in PMC: 2021 Apr 8.
Published in final edited form as: J Am Chem Soc. 2020 Mar 30;142(14):6769–6776. doi: 10.1021/jacs.0c01214

Table 1.

Ligand Investigation for β-C(sp3)–H Acetoxylationa,b

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a

Conditions: 1a (0.1 mmol), Pd(OAc)2 (10 mol%), ligand (L) (20 mol%), Na2CO3 (1.0 eq), Ac2O (2.0 eq), TBHP (70% in water) (2.0 eq), HFIP, 60 °C, 12 h.

b

The yields were determined by 1H NMR analysis of the crude product using CH2Br2 as the internal standard.

c

TBHP (~5.5 M in decane) (2.0 eq), isolated yield of the corresponding methyl ester.