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. Author manuscript; available in PMC: 2021 Apr 8.
Published in final edited form as: J Am Chem Soc. 2020 Mar 30;142(14):6769–6776. doi: 10.1021/jacs.0c01214

Table 3.

Substrate Scope for C(sp3)–H γ-, δ-, and ε-Lactonizationa,b

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a

Conditions: 4 (0.1 mmol), Pd(OAc)2 (10 mol%), L12 (20 mol%), K3PO4 (1.0 eq), TBHP (~5.5 M in decane) (2.0 eq), HFIP, 60 °C, 12 h.

b

Isolated yields of the corresponding methyl ester.