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. Author manuscript; available in PMC: 2020 May 13.
Published in final edited form as: Biochem J. 2019 Jun 14;476(11):1653–1677. doi: 10.1042/BCJ20170380

Figure 2. Hsp70 allostery is governed by the energetic competition between domain interfaces.

Figure 2.

(A) The βSBD-α-lid interface (red) formed in the undocked state of DnaK (PDB ID 2kho [12]) and (B) the NBD–SBD interface (blue) formed in the docked state of DnaK (PDB ID 4b9q [17]). (C) Schematic representation of the allosteric cycle of DnaK. Coloring follows the scheme described in Figure 1.