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. Author manuscript; available in PMC: 2020 May 13.
Published in final edited form as: Biochem J. 2019 Jun 14;476(11):1653–1677. doi: 10.1042/BCJ20170380

Figure 5. The prokaryotic NEF GrpE.

Figure 5.

(A) Structure of E. coli DnaK GrpE (PDB ID: 1dkg [90]). (B) GrpE (green) in complex with the NBD of E. coli DnaK (blue). (C) Conformational changes in the NBD caused by GrpE binding. ADP-bound NBD is shown in light blue (homology model based on PDB ID 3hsc [92]) and GrpE-bound NBD in blue. The red arrow indicates the movement of subdomain IIB caused by GrpE binding. (D) Crystal structure of full-length DnaK from G. kaustophilus with its corresponding GrpE (PDB ID: 4ani [98]). The domains of DnaK are colored as in Figure 1.