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. Author manuscript; available in PMC: 2021 May 11.
Published in final edited form as: Angew Chem Int Ed Engl. 2020 Mar 11;59(20):7783–7787. doi: 10.1002/anie.202000632

Table 1.

Directing group and ligand screening.[a]

graphic file with name nihms-1584748-t0005.jpg
[a]

Yields were determined by 1H NMR using dibromomethane as internal standard. Condition A: Substrate 1 (0.1 mmol), aryl iodide (0.3 mmol), Pd(OAc)2 (10 mol%), AgOAc (2.5 equiv), Li2CO3 (2.0 equiv) in DCE (1.0 mL), 120 °C, 24 h; Condition B: Substrate 1 (0.1 mmol), aryl iodide (0.3 mmol), Pd(OAc)2 (10 mol%), Ligand (40 mol%), AgTFA (1.5 equiv), in HFIP (1.0 mL), 100 °C, 4 h.

[b]

Ligand L6 was used with condition B.

[c]

No reaction under condition B.

[d]

No reaction under condition A.

[e]

Using condition B and DG9 as directing group.