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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: J Endocrinol. 2020 Jun;245(3):R23–R48. doi: 10.1530/JOE-20-0044

Table 2:

Induction of hyperandrogenemic maternal hormone milieu by developmental insults.

Maternal Insult Maternal Androgen Milieu
Disease State
  • PCOS

  • Virilizing CAH

  • Gestational diabetes

  • Preeclampsia


Sir-Petermann et al, 2002
Parsa and New, 2017
Morisset et al, 2013
Acromite et al, 1999
Undernutrition Mossa et al, 2019
Overnutrition Pasquali and Oriolo, 2019
Maliqueo et al, 2017
Arnon et al, 2016
Whyte et al, 2007
Stress Barrett and Swan, 2015
EDC - Bisphenol A Rutkowska and Rachon, 2014 Takeuchi et al, 2004
EDC - Phthalates Sathyanarayana et al, 2017

PCOS = polycystic ovary syndrome; CAH = congenital adrenal hyperplasia; EDC = endocrine-disrupting chemical