Table 2.

Associations Between Pulse Pressure (PP) and Mean Arterial Pressure (MAP) at Study Entry and Regional White Matter Hyperintensity Volume at MRI Visit

	Beta	LCL	UCL
Frontal
PP (z-score)	1.014	−3.207	5.419
MAP (z-score)	6.670	2.293	11.233
Parietal
PP (z-score)	−1.097	−5.230	3.215
MAP (z-score)	4.787	0.488	9.271
Temporal
PP (z-score)	1.671	−2.577	6.105
MAP (z-score)	1.408	−2.752	5.747
Anterior PV
PP (z-score)	0.728	−3.481	5.120
MAP (z-score)	10.909	6.359	15.654
Posterior PV
PP (z-score)	0.130	−4.054	4.496
MAP (z-score)	7.681	3.263	12.288
Occipital
PP (z-score)	0.674	−3.197	4.700
MAP (z-score)	2.219	−1.645	6.235

PP=pulse pressure and MAP=mean arterial pressure. PP and MAP expressed as z-score units. Estimates are transformed such that they represent the expected percent change in WMHV per z-score unit of PP and MAP. Model adjusted for age, sex, race/ethnicity, TIV, BMI, brain region, smoking status, anti-hypertensive medication use, any physical activity, moderate alcohol consumption, diabetes, hyperlipidemia, years between baseline and MRI, and two-way multiplicative interaction terms between brain region and age, sex, race/ethnicity, TIV, anti-hypertensive medication use, smoking status, diabetes, and years between baseline and MRI.