Table 2.
Associations Between Pulse Pressure (PP) and Mean Arterial Pressure (MAP) at Study Entry and Regional White Matter Hyperintensity Volume at MRI Visit
Beta | LCL | UCL | |
---|---|---|---|
Frontal | |||
PP (z-score) | 1.014 | −3.207 | 5.419 |
MAP (z-score) | 6.670 | 2.293 | 11.233 |
Parietal | |||
PP (z-score) | −1.097 | −5.230 | 3.215 |
MAP (z-score) | 4.787 | 0.488 | 9.271 |
Temporal | |||
PP (z-score) | 1.671 | −2.577 | 6.105 |
MAP (z-score) | 1.408 | −2.752 | 5.747 |
Anterior PV | |||
PP (z-score) | 0.728 | −3.481 | 5.120 |
MAP (z-score) | 10.909 | 6.359 | 15.654 |
Posterior PV | |||
PP (z-score) | 0.130 | −4.054 | 4.496 |
MAP (z-score) | 7.681 | 3.263 | 12.288 |
Occipital | |||
PP (z-score) | 0.674 | −3.197 | 4.700 |
MAP (z-score) | 2.219 | −1.645 | 6.235 |
PP=pulse pressure and MAP=mean arterial pressure. PP and MAP expressed as z-score units. Estimates are transformed such that they represent the expected percent change in WMHV per z-score unit of PP and MAP. Model adjusted for age, sex, race/ethnicity, TIV, BMI, brain region, smoking status, anti-hypertensive medication use, any physical activity, moderate alcohol consumption, diabetes, hyperlipidemia, years between baseline and MRI, and two-way multiplicative interaction terms between brain region and age, sex, race/ethnicity, TIV, anti-hypertensive medication use, smoking status, diabetes, and years between baseline and MRI.