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. 2020 May 13;15(5):e0232235. doi: 10.1371/journal.pone.0232235

Fig 4. CAV1 protein expression in ovarian cancer tissues.

Fig 4

A, B) High expression of CAV1 in the tumor cells and fibroblasts, positive in the vascular endothelial cells of ovarian serous cancer tissues; C, D) High expression of CAV1 in the cancer cells, negative in the inflammatory cells of ovarian endometrioid cancer tissues; E) Low expression of CAV1 in the cancer cells, high expression in the fibroblasts of ovarian mucinous cancer tissues; F) Low expression of CAV1 in the cancer cells and fibroblasts, negative in the inflammatory cells, positive in the vascular endothelial cells of ovarian endometrioid cancer tissues (A, C, E, F: 100×IHC; B, D: 200×IHC). ATG4C protein was highly expressed in EOC cells, primarily localized in the cell membrane and cytoplasm, moreover, there was positive ATG4C expression in cancer-related fibroblasts (CAFs) and inflammatory cells (Fig 5). Among EOC tissues, high expression of ATG4C in cancer cells and stromal cells was 70.5% (67/95) and 31.6% (25/79) respectively, which was higher than that in noncancerous ovarian tissues.