(A) Effects of 2–10 FSS pulses on the viability of freshly isolated prostate cancer cells from tumor-bearing mice (Pten−/− and Pten−/−;Trp53−/−) and on wild-type prostate epithelial cells (****p < 0.0001, two-way ANOVA).
(B) Effects of 2–10 FSS pulses on cells derived from primary and metastatic human melanoma PDX tumors (p > 0.05, two-way ANOVA).
(C) Effects of staurosporine treatment versus vehicle only (DMSO) on FSS resistance (****p < 0.0001, n = 4; two-way ANOVA, n = 3). Data are presented as mean with SEM error bars.
See also Figure S1.