Table 3.
Relationship between resting state functional connectivity of the left pedunculopontine nuclei and clinical characteristics in PTSD+DS individuals.
| PTSD+DS | L/R | Brain region | k | Z | p FWEcorr | p uncorr | Peak MNI
Coordinate |
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| x | y | z | ||||||||||
| LPPN | PTSD symptom severity | R | ↓ | Caudate | ** | 79 | 4.38 | .009 | <.001 | 4 | 0 | 4 |
| State derealization/depersonalization | R | ↓ | Thalamus (anterior nucleus) | ** | 124 | 4.45 | .007 | <.001 | 8 | −4 | 4 | |
ROI approach: rsFC results are reported at a local significance threshold of **p < .0125 (i.e., adjusted for number of ROIs), FWE corrected. PTSD: post-traumatic stress disorder; PTSD+DS: PTSD with the dissociative subtype; L: left; R: right; n.s.: no significant difference; k: cluster size; puncorr: p-value, uncorrected for multiple comparisons; pFWEcorr: p-value, corrected for multiple comparisons (FWE); ↓: negative correlation; FWE: family-wise error; MNI: Montreal Neurological Institute; LPPN: left peduncolopontine nuclei.