(A) High-magnification images of histological sections of (A) 0C0S, (B) 45C0S, (C) 10C35S, and (D) 0C45S at 4, 12 and 18 months stained with Stevenel’s Blue show evidence of new bone formation. Near the periphery, intramembranous ossification was observed, indicated by woven bone formation (double yellow arrows). By 18 months, mature lamellar bone formation (single yellow arrows) is seen within all samples. (Scale bar = 200 μm, single arrow: woven bone, double arrows: mature lamellar bone).