Table 2.
Comparison between patients with Kawasaki-like disease presenting before and after the SARS-CoV-2 epidemic
| Group 1 | Group 2 | p value | ||
|---|---|---|---|---|
| Time of presentation | Until February, 2020 | March–April, 2020 | NA | |
| Number of patients | 19 | 10 | NA | |
| Age at onset, years | 3·0 (2·5) | 7·5 (3·5) | 0·00035 | |
| Incidence | 0·3 per month | 10 per month | <0·00001 | |
| Sex | NA | NA | 0·13 | |
| Female | 12 | 3 | NA | |
| Male | 7 | 7 | NA | |
| Incomplete Kawasaki disease | 6/19 (31%) | 5/10 (50%) | 0·43 | |
| CRP, mg/dL | 16·3 (8·0) | 25 (15·3) | 0·05 | |
| ESR, mm/h | 82 (29) | 72 (24) | 0·38 | |
| White cell count, × 109 per L | 19·4 (6·4) | 10·8 (6·1) | 0·0017 | |
| Neutrophils | 71·9% (17·2) | 84·5% (5·7) | 0·034 | |
| Lymphocytes, × 109 per L | 3·0 (1·8) | 0·86 (0·4) | 0·0012 | |
| Haemoglobin, g/dL | 10·8 (2·0) | 11 (1·2) | 0·79 | |
| Platelets, × 109 per L | 457 (96) | 130 (32) | <0·00001 | |
| Albumin, g/dLl | 3·3 (0·5) | 3·2 (0·3) | 0·55 | |
| Sodium, mEq/L | 134·7 (1·6) | 130·8 (3·9) | 0·0011 | |
| AST, U/L | 120 (218) | 87 (70) | 0·64 | |
| ALT, U/L | 92 (122) | 119 (217) | 0·67 | |
| Ferritin, ng/mL | 187 (89) | 1176 (1032) | 0·011 | |
| Triglycerides, mg/dL | .. | 239 (108) | .. | |
| Fibrinogen, mg/dL | 543 (300) | 621 (182) | 0·51 | |
| D-dimer, ng/mL | 3244 (943) | 3798 (1318) | 0·52 | |
| CPK, IU/L | 61 (28) | 85 (64) | 0·19 | |
| Troponin I, ng/L | .. | 1004 (1862) | .. | |
| proBNP, ng/L | .. | 1255 (929) | .. | |
| Kobayashi score ≥5 | 2/19 (10%) | 7/10 (70%) | 0·0021 | |
| MAS18 | 0/10 (0%) | 5/10 (50%) | 0·021 | |
| KDSS14 | 0/10 (0%) | 5/10 (50%) | 0·021 | |
| Abnormal echocardiography | 2/19 (10%) | 6/10 (60%) | 0·0089 | |
| Adjunctive steroid treatment | 4/19 (16%) | 8/10 (80%) | 0·0045 | |
| Inotropes treatment | 0/19 (0%) | 2/10 (20%) | 0·11 | |
| Response to treatment | 19/19 (100%) | 10/10 (100%) | 1 | |
Data are mean (SD) or n/N (%), unless otherwise stated. SARS-CoV-2=severe acute respiratory syndrome coronavirus 2. NA=not applicable. CRP=C-reactive protein. ESR=erythrocyte sedimentation rate. AST=aspartate aminotransferase. ALT=alanine aminotransferase. CPK=creatine phosphokinase. BNP=B-type natriuretic peptide. MAS=Macrophage Activation Syndrome. KDSS=Kawasaki disease shock syndrome.