Figure 2. Folic acid therapy effect on first ischemic stroke by B₁₂/folate subgroups and methylenetetrahydrofolate reductase (MTHFR 677) genotypes (CC/TT).

Effect of folic acid therapy on first ischemic stroke by vitamin B₁₂ (median <280.2 vs ≥280.2 pmol/L) and folate (median <8.1 vs ≥8.1 ng/mL) subgroups and MTHFR C677T genotypes (CC and TT genotype) in the total population. *Group 1: B₁₂ <280.2 pmol/L and folate <8.1 ng/mL; group 2: B₁₂ < 280.2 pmol/L and folate ≥8.1 ng/mL; group 3: B₁₂ ≥280.2 pmol/L and folate <8.1 ng/mL; group 4: B₁₂ ≥280.2 pmol/L and folate ≥8.1 ng/mL; adjusted for age, sex, body mass index, systolic and diastolic blood pressure, study centers, creatinine, total cholesterol, triglycerides, HDL cholesterol, fasting glucose, smoking and alcohol drinking status at baseline, and mean systolic and diastolic blood pressure during the treatment period. CI = confidence interval.