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. 2020 May 13;6(20):eaay5898. doi: 10.1126/sciadv.aay5898

Table 1. Selected AMPs and anti-Plasmodium peptides for transgenic expression in the genetically modified mosquitoes.

Effectors Characterization Parasite stage(s) Function or
mechanism
Expression
method
Inhibition (%) Reference
Melittin Bee antimicrobial
peptides
Ookinete Lysis of parasites Synthesized 100.0% (27)
TP10 dimer Wasp antimicrobial
peptides
Ookinete Lysis of parasites Synthesized 100.0% (2527)
Shiva1 Cecropin-like
synthetic peptide
Gametes Ookinete Lysis of parasites Para-transgenesis 94.3% (27)
EPIP four repeats Enolase-
plasminogen
interaction peptide
Ookinete Block midgut
invasion
Para-transgenesis 97.7% (20)
Scorpine Scorpion venom Gametogenesis
Ookinete
Cecropin and
defensin-like lytic
peptide
Para-transgenesis 97.8% (23)