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. 2019 Jun 20;11(3):588–602. doi: 10.14336/AD.2019.0620

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Copyright: © 2020 Ban et al.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 1. — Effects of linagliptin on renal function and aging-related renal injury histology. (A) Serum creatinine levels were increased in the AM group compared to the AM group (p < 0.001), and decreased in the AM + LIN group compared to the AM group (p < 0.05). (B) Albuminuria was increased in the AM group, but it was not different in the AM and AM + LIN groups. (C) Creatinine clearance was decreased in the AM group, but it was similar in the AM and AM + LIN groups. (D) Serum cystatin-C levels were increased in the AM group compared to the AM group (p < 0.001) and decreased in the AM + LIN group compared to the AM group (p < 0.05). (E) The expansion of the mesangial area of PAS-stained kidneys was significantly reduced in the AM + LIN group (original magnification ×400). (F) Decreased tubulointerstitial fibrosis was observed in Masson’s trichrome-stained kidney sections from the AM + LIN group (original magnification ×400). (G) The areas of extracellular matrix in the glomerulus and (H) the areas of tubulointerstitial fibrosis determined using a quantitative assessment were definitely decreased in the AM + LIN group (p < 0.001 for both). (*p < 0.05 and ‡p < 0.001).