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. 2019 Jun 20;11(3):588–602. doi: 10.14336/AD.2019.0620

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Copyright: © 2020 Ban et al.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 2. — Effects of linagliptin on fibrosis and inflammation in renal tissue. (A) The numbers of collagen IV-, (B) TGF-β- and (C) MCP-1-positive cells were decreased in the AM + LIN group compared to the AM group. (D), (E) and (F) The areas positive for collagen IV, TGF-β and MCP-1 were markedly increased in the AM + LIN group. (G) Levels of markers fibrosis and inflammation were analyzed using western blotting. (H) and (I) Comparison of fibronectin and collagen IV levels between the three groups. (J) and (K) Comparison of TGF-β and CTGF levels between the three groups. (*p < 0.05, †p < 0.01, and ‡p < 0.001).