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. 2019 Jun 20;11(3):588–602. doi: 10.14336/AD.2019.0620

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Copyright: © 2020 Ban et al.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 4. — Effects of linagliptin on angiotensin II levels and PRR, ACE and AT1R protein expression in kidneys. (A) The levels of Ang II in the kidneys were decreased in the AM + LIN group compared with the AM group (p < 0.05). (B) Representative western blots of PRR, ACE and AT1R protein expression. (C) Lower levels of the PRR protein were detected in the AM + LIN group than in the AM group (p < 0.05). (D) Lower levels of the ACE protein were observed in the AM + LIN group than in the AM group (p < 0.01). (E) Lower levels of the AT1R protein were observed in the AM + LIN group than in the AM group (p < 0.01). (*p < 0.05, †p < 0.01, and ‡p < 0.001).