Table 1.
Characteristics of the included studies and meta-analysis of the clinical symptoms and comorbid chronic diseases in patients with COVID-19.
| Study[ref]a | NOS | Dates (mm. yy) | n
|
Age (years) | Age ≥50 years (%) | Symptoms (%)
|
Comorbidities(%)
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| All | M | F | fever | cough | fatigue or myalgia | shortness of breath or dyspnea | diarrhea | diabetes | hypertension | CAD/CVD | chronic pulmonary disease | |||||
| Guan et al.,2020 [3] | 8 | 12.19-01.20 | 1099 | 640 | 459 | 47.0 | 44.0 | 88.7 | 67.8 | 38.1 | 18.7 | 3.8 | 7.4 | 15.0 | 2.5 | 1.1 |
| Chen et al.,2020 [4] | 7 | 01.20-01.20 | 99 | 67 | 32 | 55.5 | 67.7 | 82.8 | 81.8 | 11.0 | 31.3 | 2.0 | 13.0 | b | 40.0 | 1 |
| Huang et al.,2020 [18] | 6 | 12.19-01.20 | 41 | 30 | 11 | 49.0 | 48.8 | 98.0 | 76.0 | 44.0 | 55.0 | 3.0 | 20.0 | 15.0 | 15.0 | 2.0 |
| Liu et al.,2020 [8] | 7 | 12.19-01.20 | 137 | 61 | 76 | 55.0 | b | 81.8 | 48.2 | 32.1 | 19.0 | 8.0 | 10.2 | 9.5 | 7.3 | 1.5 |
| Shi et al.,2020 [22] | 6 | 12.19-01.20 | 81 | 42 | 39 | 49.5 | 49.4 | 73.0 | 59.0 | b | 42.0 | 4.0 | 12.0 | 15.0 | 10.0 | 11 |
| Song et al.,2020 [20] | 6 | 01.20-01.20 | 51 | 25 | 26 | 49.0 | 47.1 | 96.0 | 47.0 | 31.0 | 14.0 | 10.0 | 6.0 | 10.0 | 2.0 | 2.0 |
| Yang et al.,2020 [6] | 7 | 12.19-01.20 | 52 | 35 | 17 | 59.7 | 55.0 | 98.0 | 77.0 | 11.5 | 63.5 | b | 17.0 | b | 10.0 | 8 |
| Xu et al.,2020 [19] | 7 | 01.20-01.20 | 62 | 35 | 27 | 41.0 | b | 77.0 | 81.0 | 52.0 | b | 8.0 | 2.0 | 8.0 | b | 2.0 |
| Zhang et al.,2020 [15] | 8 | 01.20-02.20 | 140 | 71 | 69 | 57.0 | 70.0 | 78.6 | 64.3 | 64.3 | 31.4 | 12.9 | 12.1 | 30.0 | 5.0 | 2.8 |
| Wu et al.,2020 [16] | 7 | 01.20-02.20 | 80 | 39 | 41 | 46.0 | 35.0 | 78.8 | 63.8 | 22.5 | 37.5 | 1.3 | 6.3 | b | 31.3 | 1.25 |
| Hu et al.,2020 [14] | 6 | 01.20-02.20 | 24 | 8 | 16 | 32.5 | 37.5 | 20.8 | 8.3 | 8.3 | b | b | 8.3 | 8.3 | 4.2 | 0.0 |
| Huang et al.,2020 [17] | 7 | 12.19-01.20 | 34 | 14 | 20 | 56.2 | b | 94.1 | 50.0 | 64.7 | 14.7 | 14.7 | 11.8 | 23.5 | 17.6 | 8.8 |
| Yang et al.,2020 [13] | 8 | 01.20-02.20 | 149 | 81 | 68 | 45.1 | b | 76.5 | 58.4 | 3.4 | 1.3 | 7.4 | 6.0 | b | 18.8 | 0.7 |
| Wang et al.,2020 [5] | 7 | 01.20-01.20 | 138 | 75 | 63 | 56.0 | b | 98.6 | 59.4 | 69.6 | 31.2 | 10.1 | 10.1 | 31.2 | 14.5 | 2.9 |
| Xu et al.,2020 [21] | 7 | 01.20-02.20 | 90 | 39 | 51 | 50.0 | b | 78.0 | 63.0 | 28.0 | b | 6.0 | 6.0 | 19.0 | 3.0 | 1.0 |
| Li et al.,2020 [12] | 7 | 01.20-02.20 | 83 | 44 | 39 | 45.5 | b | 86.7 | 78.3 | 18.1 | 10.8 | 8.4 | 7.8 | 6.0 | 1.2 | 6.0 |
| Shi et al.,2020 [23] | 8 | 01.20-02.10 | 416 | 205 | 211 | 64 | b | 80.3 | 34.6 | 13.2 | 28.1 | 3.8 | 14.4 | 30.5 | 10.6 | 2.9 |
| Bhatraju et al.,2020[24] | 6 | 02.20-03.20 | 24 | 15 | 9 | 64 | b | 50.0 | 88.0 | b | 88.0 | b | 58.0 | b | b | 16.7 |
| Feng et al.,2020 [25] | 7 | 01.20-02.20 | 476 | 271 | 205 | 53 | b | 81.9 | 56.5 | 11.6 | 22.9 | 10.3 | 10.3 | 23.7 | 8.0 | 4.6 |
| Du et al.,2020 [26] | 8 | 12.19-02.20 | 179 | 97 | 82 | 57.6 | 72.6 | 98.9 | 81.6 | 39.7 | 49.7 | 21.8 | 18.4 | 32.4 | 16.2 | 4.5 |
| Liu et al.,2020 [27] | 6 | 12.19-01.20 | 78 | 39 | 39 | 38 | b | 73.1 | 43.6 | b | b | b | 6.4 | 10.3 | b | 2.6 |
| Grasselli et al.,2020 [28] | 8 | 02.20-03.20 | 1591 | 1304 | 287 | 63 | 87.2 | b | b | b | b | b | 11.3 | 32.0 | 14.0 | 2.6 |
| Richardson et al.,2020[29] | 8 | 03.20-04.20 | 5700 | 3437 | 2263 | 63 | 78.5 | 30.4 | b | b | 17.3 | b | 31.8 | 53.0 | 16.9 | 8.4 |
| Simonnet et al.,2020[30] | 7 | 02.20-04.20 | 124 | 90 | 34 | 60 | 1.00 | b | b | b | b | b | 22.6 | 48.4 | b | b |
| Total/Overall | 12.19-04.20 | 10948 | 6764 | 4184 | 52.4c (32.5-64.0)d |
|||||||||||
| Prevalencee | 59.0 | 79.0 | 61.0 | 32.0 | 31.0 | 7.0 | 10.0 | 20.0 | 8.0 | 3.0 | ||||||
| 95% CI | 49.0-68.0 | 65.0-92.0 | 54.0-69.0 | 21.0-43.0 | 25.0- 37.0 |
5.0-9.0 | 8.0-12.0 | 15.0-26.0 | 3.0-12.0 | 1.0-3.0 | ||||||
| I2 (%) | 98.5 | 99.7 | 95.1 | 98.5 | 97.4 | 81.1 | 73.0 | 94.2 | 98.0 | 94.5 | ||||||
mm, month; yy, year; M, male; F, female; SE, standard error; CI, confidence interval, NOS, Newcastle-Ottawa Scale;
a
[3]- [8], [12]-[23], [25]-[27] Studies were from China; [24], [29] studies were from America; [28] study was from Italy; [30] study was from France.
b
Any empty cells represents the absence of data in the original text.
c
the median age [IQR].
d
Age range.
e
Meta-analysis for the prevalence was calculated from binary random-effects model analysis.
f
p < 0.001.