Table 2.
Association of annual telomere attrition rate with BP change during 2014-2016.
| Annual telomere | Mode I* | Model II† | |||||
|---|---|---|---|---|---|---|---|
| Change in BP | attrition rate | β | SE | P value | β | SE | P value |
| Total (n=1,108) | |||||||
| ΔSBP | Shorten (n=386) | Ref. | Ref. | ||||
| Lengthen (n=722) | -3.20 | 1.35 | 0.02 | -3.28 | 1.37 | 0.02 | |
| ΔDBP | Shorten (n=386) | Ref. | Ref. | ||||
| Lengthen (n=722) | -0.58 | 0.73 | 0.43 | -0.78 | 0.74 | 0.29 | |
| ΔPP | Shorten (n=386) | Ref. | Ref. | ||||
| Lengthen (n=722) | -2.74 | 1.10 | 0.01 | -2.53 | 1.11 | 0.02 | |
| Men (n=430) | |||||||
| ΔSBP | Shorten (n=155) | Ref. | Ref. | ||||
| Lengthen (n=275) | -2.19 | 2.14 | 0.31 | -2.68 | 2.16 | 0.15 | |
| ΔDBP | Shorten (n=155) | Ref. | Ref. | ||||
| Lengthen (n=275) | -0.78 | 1.20 | 0.52 | -1.05 | 1.19 | 0.38 | |
| ΔPP | Shorten (n=155) | Ref. | Ref. | ||||
| Lengthen (n=275) | -1.48 | 1.73 | 0.39 | -1.34 | 1.72 | 0.44 | |
| Women (n=678) | |||||||
| ΔSBP | Shorten (n=231) | Ref. | Ref. | ||||
| Lengthen (n=447) | -3.91 | 1.73 | 0.02 | -3.56 | 1.76 | 0.04 | |
| ΔDBP | Shorten (n=231) | Ref. | Ref. | ||||
| Lengthen (n=447) | -0.71 | 0.92 | 0.45 | -0.81 | 0.94 | 0.39 | |
| ΔPP | Shorten (n=231) | Ref. | Ref. | ||||
| Lengthen (n=447) | -3.42 | 1.42 | 0.02 | -3.25 | 1.44 | 0.03 | |
| ≤60 years (n=506) | |||||||
| ΔSBP | Shorten (n=169) | Ref. | Ref. | ||||
| Lengthen (n=337) | -6.41 | 1.90 | 0.001 | -6.82 | 1.91 | <0.001 | |
| ΔDBP | Shorten (n=169) | Ref. | Ref. | ||||
| Lengthen (n=337) | -2.37 | 1.10 | 0.03 | -2.49 | 1.11 | 0.03 | |
| ΔPP | Shorten (n=169) | Ref. | Ref. | ||||
| Lengthen (n=337) | -3.97 | 1.46 | 0.007 | -4.23 | 1.47 | 0.004 | |
| >60 years (n=602) | |||||||
| ΔSBP | Shorten (n=217) | Ref. | Ref. | ||||
| Lengthen (n=385) | -1.53 | 2.08 | 0.46 | -1.42 | 2.13 | 0.51 | |
| ΔDBP | Shorten (n=217) | Ref. | Ref. | ||||
| Lengthen (n=385) | 0.76 | 0.97 | 0.43 | 0.41 | 1.0 | 0.68 | |
| ΔPP | Shorten (n=217) | Ref. | Ref. | ||||
| Lengthen (n=385) | -1.46 | 1.58 | 0.35 | -1.74 | 1.77 | 0.33 | |
Abbreviations: BP, blood pressure; SBP, systolic blood pressure; DBP, diastolic blood pressure; PP, pulse pressure; β, regression β coefficients; SE, standard error; Ref., reference. *Model I and †Model II were multiple linear regression models for analyzing the correlation between annual telomere attrition rate and BP change during 2014-2016. *Model I adjusted for baseline characteristics including age, gender (except in gender-stratified analysis), BMI, waist-to-hip, smoking status, alcohol intake, medical history, the stage of baseline blood pressures, leukocytes telomere length, serum fasting glucose, total cholesterol, triglycerides, HDL-C, and LDL-C. †Model II further adjusted for changes in BMI, waist-to-hip, fasting glucose, total cholesterol, triglycerides, HDL-C, and LDL-C from 2014 to 2016, besides the covariates in Model I.