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. 2020 May 13;6(20):eaba0721. doi: 10.1126/sciadv.aba0721

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Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 1 — (A) Volatile nepetalactone stereoisomers found in Nepeta. Harpagide is a typical nonvolatile iridoid glucoside found in other iridoid-producing Lamiaceae. (B) Early iridoid biosynthetic pathway in plants: geraniol synthase (GES), geraniol 8-hydroxylase (G8H), 8-hydroxygeraniol oxidoreductase (HGO), and iridoid synthase (ISY). (C) Knowledge of nepetalactone biosynthesis in N. mussinii as reported in Lichman et al. (9). The crossed double bond depiction in the ISY product refers to unknown or undefined stereochemistry.