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. 2020 May 13;6(20):eaaz0480. doi: 10.1126/sciadv.aaz0480

Fig. 3. Dlp repression is responsible for Hh/Wnt signaling interdependence in IGS cells and for GSC progeny differentiation.

Fig. 3

(A and B) dlp knockdown in IGS cells can significantly and drastically rescue the expression of ptc-GFP and fz3-RFP in dshKD and smoKD IGS cells (arrowheads), respectively (broken ovals highlight cap cells; C) quantification results on ptc-GFP and fz3-RFP fluorescence intensities normalized to LacZ; n = IGS cell numbers. (D and E) dlp knockdown in IGS cells can significantly decrease the accumulation of SGCs (only some of them by arrowheads) caused by dshKD and smoKD (E: CB/SGC quantification results; n = germarial number). Scale bars, 10 μm. (***P ≤ 0.001; **P ≤ 0.01).