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. 2020 May 8;14:1779–1798. doi: 10.2147/DDDT.S249156

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© 2020 Feng et al.

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Scheme 1 — The synthetic route of 2a. Reagents and conditions: (A) NaOH, ethyl alcohol, rt; (B) triethylamine, methylbenzene, 100°C; (C) ethyl alcohol, 80°C.