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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Neurol Clin. 2020 Feb 27;38(2):449–467. doi: 10.1016/j.ncl.2020.01.008

Table 2:

Neuromodulation and physical exercise for ataxia

Treatment Ataxia type Evidence References
Physical merapy SCA7, SCA2, FA A randomized, open label study (llg et al., 2009; Tercero-Pérez et al., 2019; Velázquez-Pérez et al., 2019)
Transcranial magnetic stimulation SCA1, SCA6, SCA7 A randomized, sham-controlled study and case reports (Kawamura et al., 2018; Shiga et al., 2002; Shimizu et al., 1999)
Posterior circulation stroke A randomized, double-blind trial (Kim et al., 2014)
Transcranial direct current stimulation SCA, MSA, FA A randomized, double-blind, sham-controlled study and case report (Benussi et al., 2015, 2018; Grimaldi and Manto, 2013)
Deep brain stimulation SCA Case report (Hashimoto et al., 2018)
FXTAS Case report (dos Santos Ghilardi et al., 2015)
Cerebellar stroke Case report (Teixeira et al., 2015; Weiss et al., 2015)

FA: Friedreich ataxia, FXTAS: Fragile X-associated tremor/ataxia syndrome, MSA: multiple system atrophy, SCA: spinocerebellar ataxia