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. 2020 Mar 20;99(12):e18815. doi: 10.1097/MD.0000000000018815

Figure 2.

Figure 2

SREBP2 and genes of de novo cholesterol synthesis is expressed at lower levels in GBM than in LGG. (A-H) Box plots of mRNA expression of cholesterol synthesizing enzyme coding genes (HMGCR, HMGCS1, FDFT1, LSS, and CYP46A1) in LGG (G2 and G3) and GBM from TCGA database. (I) Heatmap shows that expression of SREBP2 and genes involved in cholesterol synthesis is significantly lower in GBM than in LGG. WHO Grade 2, n = 216; Grade 3, n = 241; Grade 4, n = 160, Student t test, ∗, P < .05; ∗∗, P < .01; ∗∗∗P < .001; n.s., not significant.