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. 2020 Mar 20;99(12):e18815. doi: 10.1097/MD.0000000000018815

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Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc.

This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY NC), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0

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Expression of genes involved in cholesterol excretion is lower in GBM. Conversion to oxysterol is the major outlet for cholesterol excretion in the brain. CYP46A1 is the major enzyme in the brain that converts cholesterol to 24-hydroxycholesterol (24-OHC). CYP46A1 (A) and ABCG1 (C) mRNA is expressed higher in LGG than in GBM, while expression of ABCA1 (B), the other major gene involved in cholesterol excretion, is not significantly different between LGG and GBM. WHO Grade 2, n = 216; Grade 3, n = 241; Grade 4, n = 160, Student t test, ^∗, P < .05; ^∗∗, P < .01; ^∗∗∗P < .001; n.s., not significant.