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. 2019 Dec 4;69(2):189–198. doi: 10.1538/expanim.19-0120

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©2020 Japanese Association for Laboratory Animal Science

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)

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Fig. 2. — Phenotypical and genotypical analysis of Il2rg-targeted F0 founders. Phenotyping with flow cytometry and genotyping with Surveyor assays of founder mice. (A, C, E) Electrophoresis results of Surveyor assays. Expected mutated bands are indicated with black asterisks. (B, D, F) Flow cytometry results: Black bars, the numbers of CD3⁺ T cells; white bars, the numbers of CD19⁺ B cells in the peripheral blood of the mice. (G) Representative flow cytometry results showing the reductions of T and B cells and the existence of granulocytes (Gr⁺/CD11b⁺ cells) in the peripheral blood of Il2rg Ex2 #2, Ex3 #1 and Ex4 #5 mice.