Table 2:
Comparisons between baseline and post-treatment changes in olfactory function and PROM scores for study participants with follow-up.
| Outcomes: | Baseline Median [IQR] | Follow-up Median [IQR] | Difference (Δ) Median [IQR] | Matched pairing test statistic | p-value |
|---|---|---|---|---|---|
| Lund-Kennedy endoscopy score (n=33) | 7.0 [6.0] | 6.0 [5.0] | 0.0 [5.5] | WSR=−1.08 | 0.283 |
| Sniffin’ Sticks / TDI total score (n=33) | 24.8 [36.0] | 27.5 [12.6] | 1.5 [4.1] | WSR= 1.60 | 0.109 |
| Threshold score | 3.0 [5.5] | 4.0 [5.5] | 0.0 [1.8] | WSR= 0.85 | 0.396 |
| Discrimination score | 10.0 [6.0] | 11.0 [5.8] | 1.0 [5.5] | WSR= 0.77 | 0.444 |
| Identification score | 12.0 [8.0] | 12.0 [5.0] | 0.0 [2.5] | WSR= 1.09 | 0.277 |
| SNOT-22 total score (n=39) | 43.0 [30.0] | 26.0 [22.0] | −12.0 [32.0] | WSR= −3.66 | <0.001 |
| Rhinologic symptoms | 15.0 [12.0] | 9.0 [6.0] | −4.0 [12.0] | WSR= −3.67 | <0.001 |
| Extranasal rhinologic symptoms | 7.0 [7.0] | 5.0 [6.0] | −2.0 [5.0] | WSR= −3.01 | 0.003 |
| Ear / facial symptoms | 6.0 [7.0] | 4.0 [6.0] | −1.0 [6.0] | WSR= −3.15 | 0.002 |
| Psychological dysfunction symptoms | 9.0 [12.0] | 6.5 [9.0] | −3.0 [8.0] | WSR= −2.96 | 0.003 |
| Sleep dysfunction symptoms | 9.0 [10.0] | 5.0 [10.0] | −3.0 [9.0] | WSR= −3.29 | 0.001 |
| Q21: “Sense of smell/taste” | 3.0 [4.0] | 1.5 [3.0] | 0.0 [2.0] | WSR= −2.45 | 0.014 |
| QOD-NS total score (n=39) | 8.0 [13.0] | 8.0 [10.0] | −2.0 [5.3] | WSR= −2.01 | 0.044 |
PROM, patient reported outcome measures; TDI, odorant threshold, discrimination, identification; SNOT-22, 22-item Sinonasal Outcome Test; QOD-NS, Questionnaire of Olfactory Disorders – negative statements. WSR, Wilcoxon Signed Rank test statistic for nonparametric data (standardized); IQR, interquartile range.