Table 2.
Sociodemographic and clinical characteristics of 35 patients with Helicobacter pylori positive gastric cancer and 56 patients with H. pylori negative gastric cancer. Additional comparison included 26 patients with suspected H. pylori gastric cancer (i.e., atrophic gastritis or gastric intestinal metaplasia on gastric biopsy in the setting of negative H. pylori testing).
| H. pylori Positive Gastric Cancer (n=35) | H. pylori Negative Gastric Cancer (n=56) | p-value | H. pylori Positive Gastric Cancer (including suspected) (n=61) | H. pylori Negative Gastric Cancer (excluding suspected) (n=30) | p-value | |
|---|---|---|---|---|---|---|
| Age, mean (SD) | 66.4 (10.5) | 69.0 (10.9) | 0.270 | 68.2 (9.5) | 67.6 (13.2) | 0.784 |
| Sex | ||||||
| Male | 35 (100.0) | 52 (92.9) | 0.294 | 59 (96.7) | 28 (93.3) | 0.596 |
| Female | 0 (0.0) | 4 (7.1) | 2 (3.3) | 2 (6.7) | ||
| Race | ||||||
| Non-Hispanic White | 8 (22.8) | 21 (37.5) | 0.441 | 17 (27.9) | 12 (40) | 0.065 |
| Black | 21 (60.0) | 26 (46.4) | 33 (54.1) | 14 (46.7) | ||
| Hispanic | 5 (14.3) | 6 (10.7) | 10 (16.4) | 1 (3.3) | ||
| Other | 1 (2.9) | 3 (5.4) | 1 (16) | 3 (10.0) | ||
| BMI | ||||||
| <25 | 6 (17.1) | 9 (16.1) | 0.680 | 10 (16.4) | 5 (16.7) | 0.794 |
| 25–29 | 9 (25.7) | 20 (35.7) | 18 (29.5) | 11 (36.7) | ||
| ≥30 | 20 (57.2) | 27 (48.2) | 33 (54.1) | 14 (46.6) | ||
| GERD | ||||||
| Yes | 12 (34.3) | 24 (42.9) | 0.416 | 22 (36.1) | 14 (46.7) | 0.331 |
| No | 23 (65.7) | 32 (57.1) | 39 (63.9) | 16 (53.3) | ||
| Dyspepsia | ||||||
| Yes | 13 (37.1) | 23 (41.1) | 0.709 | 22 (36.1) | 14 (46.7) | 0.331 |
| No | 22 (62.9) | 33 (58.9) | 39 (63.9) | 16 (53.3) | ||
| PPI in last 10 years | ||||||
| Yes | 21 (60.0) | 30 (53.6) | 0.548 | 34 (55.7) | 17 (56.7) | 0.933 |
| No | 14 (40.0) | 26 (46.4) | 27 (44.3) | 13 (43.3) | ||
| Smoking History | ||||||
| Never | 6 (17.1) | 15 (26.8) | 0.468 | 11 (18.0) | 10 (33.3) | 0.259 |
| Previous | 17 (48.6) | 27 (48.2) | 31 (50.8) | 13 (43.3) | ||
| Current | 12 (34.3) | 14 (25.0) | 19 (31.2) | 7 (23.3) | ||
| Alcohol Drinking History | ||||||
| Never | 14 (40.0) | 23 (41.1) | 0.146 | 28 (45.9) | 9 (30.0) | 0.045 |
| Previous | 7 (20.0) | 20 (35.7) | 13 (21.3) | 14 (46.7) | ||
| Current | 14 (40.0) | 13 (23.2) | 20 (32.8) | 7 (23.3) | ||
| Family History of Gastric Cancer | ||||||
| Yes | 4 (11.4) | 5 (8.9) | 0.411 | 4 (6.6) | 5 (16.7) | 0.110 |
| No | 30 (85.7) | 45 (80.4) | 54 (88.5) | 21 (70.0) | ||
| Missing | 1 (2.9) | 6 (10.7) | 3 (4.9) | 4 (13.3) | ||
| Gastritis | ||||||
| No | 0 (0.0) | 2 (3.6) | 0.004 | 1 (16) | 1 (3.3) | <0.0001 |
| Active/Acute | 24 (68.6) | 18 (32.1) | 36 (59.0) | 6 (20.0) | ||
| Chronic | 7 (20.0) | 17 (30.4) | 18 (29.5) | 6 (20.0) | ||
| Missing | 4 (11.4) | 19 (33.9) | 6 (9.9) | 17 (56.7) | ||
| Atrophic Gastritis | ||||||
| Yes | 9 (25.7) | 2 (3.6) | 0.002 | 11 (18.0) | 30 (100.0) | -- |
| No | 26 (74.3) | 54 (96.4) | 50 (82.0) | 0 (0.0) | ||
| Gastric Intestinal Metaplasia | ||||||
| Yes | 26 (74.3) | 26 (46.4) | 0.009 | 52 (85.2) | 30 (100.0) | -- |
| No | 9 (25.7) | 30 (53.6) | 9 (14.8) | 0 (0.0) | ||
SD: standard deviation; BMI: body mass index; GERD: gastroesophageal reflux disease; PPI: proton pump inhibitor