Table 3.
Comparison of histopathologic and cancer-related outcomes between 35 patients with Helicobacter pylori positive gastric cancer and 56 patients with H. pylori negative gastric cancer. Additional comparison included 26 patients with suspected H. pylori gastric cancer (i.e., atrophic gastritis or gastric intestinal metaplasia on gastric biopsy in the setting of negative H. pylori testing).
| H. pylori Positive Gastric Cancer (n=35) | H. pylori Negative Gastric Cancer (n=56) | p-value | H. pylori Positive Gastric Cancer (including suspected) (n=61) | H. pylori Negative Gastric Cancer (excluding suspected) (n=30) | p-value | |
|---|---|---|---|---|---|---|
| Cancer Stage | ||||||
| Early (stage 0–1) | 12 (34.3) | 16 (28.6) | 0.308 | 23 (37.7) | 5 (16.7) | 0.037 |
| Late (stage 2–4) | 23 (65.7) | 36 (64.3) | 37 (60.7) | 22 (73.3) | ||
| Missing | 0 (0.0) | 4 (7.1) | 1 (16) | 3 (10.0) | ||
| Median survival, months | 17.3 (5.9–51.8) | 14.9 (5.0–28.0) | 0.767 | 15.1 (7.0–33.6) | 12.3 (2.9–26.7) | 0.711 |
| Cancer-related Death | ||||||
| Yes | 18 (51.4) | 31 (55.4)) | 0.49 | 29 (47.5) | 20 (66.7) | 0.166 |
| No | 16 (45.7) | 25 (44.6) | 31 (50.8) | 10 (33.3) | ||
| Missing | 1 (2.9) | 0 (0.0) | 1 (16) | 0 (0.0) | ||
| Chemotherapy | ||||||
| Yes | 17 (48.6) | 26 (46.5) | 0.860 | 27 (44.3) | 16 (53.3) | 0.441 |
| No | 14 (40.0) | 25 (44.6) | 29 (47.5) | 10 (33.3) | ||
| Missing | 4 (11.4) | 5 (8.9) | 5 (8.2) | 4 (13.4) | ||
| Radiation | ||||||
| Yes | 2 (5.7) | 13 (23.2) | 0.086 | 9 (14.8) | 6 (20.0) | 0.531 |
| No | 29 (82.9) | 38 (67.9) | 47 (77.0) | 20 (67.7) | ||
| Missing | 4 (11.4) | 5 (8.9) | 5 (8.2) | 4 (13.3) | ||
| Surgery | ||||||
| Yes | 12 (34.3) | 16 (28.6) | 0.389 | 23 (37.7) | 5 (16.7) | 0.118 |
| No | 19 (54.3) | 37 (66.1) | 34 (55.7) | 22 (73.3) | ||
| Missing | 4 (11.4) | 3 (5.4) | 4 (6.6) | 3 (10.0) | ||
| Endoscopic Resection | ||||||
| Yes | 6 (17.2) | 3 (5.4) | 0.095 | 9 (14.8) | 0 (0.0) | 0.054 |
| No | 25 (71.4) | 50 (89.2) | 48 (78.7) | 27 (90.0) | ||
| Missing | 4 (11.4) | 3 (5.4) | 4 (6.5) | 3 (10.0) | ||