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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Environ Pollut. 2020 Feb 20;261:114183. doi: 10.1016/j.envpol.2020.114183

Figure 4. Inulin decreases aortic root lesion area in Ldlr deficient mice.

Figure 4.

Male Ldlr−/− mice were fed a high cholesterol diet containing 8% cellulose or 8% inulin for 12 weeks and exposed to PCB 126 (1μmol/kg) or vehicle at weeks 2 and 4. A) Extent of atherosclerosis was determined by oil red-o staining of the aortic root. B and C) Representative cross section of the aortic roots from cellulose+PCB (B) and inulin+PCB (C) mice. Inulin significantly decreased lesion formation irrespective of treatment and mice fed the diet enriched with inulin and exposed to PCB 126 exhibited significantly decreased lesion formation compared to mice fed the control diet and exposed to PCB 126. (n=9–10 per group), Statistical significance is denoted by * (p<0.05).