Table 2.

Characteristics of the tumour and their association with survival

Variable	Category	N (%)	Hazard ratio (95% CI)*	p
Histology	Ductal	1276 (75.73)	1 (ref)
	Lobular	110 (6.53)	1.12 (0.68 to 1.83)	0.666
	Other	299 (17.74)	0.44 (0.26 to 0.72)	0.001
Tumour size	T1	876 (51.99)	1 (ref)
	T2	424 (25.16)	1.62 (1.04 to 2.52)	0.031
	T3	73 (4.33)	2.04 (1.13 to 3.68)	0.018
	T4	39 (2.31)	1.96 (0.98 to 3.91)	0.056
	Tis	109 (6.47)	0.14 (0.02 to 0.91)	0.04
	Missing	141 (8.37)	1.12 (0.61 to 2.06)	0.718
Node infiltration	N0	877 (52.05)	1 (ref)
	N1	441 (26.17)	1.16 (0.76 to 1.78)	0.481
	N2	142 (8.43)	1.17 (0.58 to 2.36)	0.651
	N3	49 (2.91)	1.73 (0.81 to 3.72)	0.158
	Missing	176 (10.45)	1.15 (0.65 to 2.03)	0.641
Tumour stage	0	112 (6.65)	0.68 (0.26 to 1.81)	0.444
	I	594 (35.25)	1 (ref)
	II	498 (29.55)	2.30 (1.46 to 3.61)	> 0.001
	III	187 (11.10)	4.23 (2.60 to 6.88)	> 0.001
	IV	42 (2.49)	29.5 (16.9 to 51.6)	> 0.001
Oestrogen receptor	Positive	1398 (82.97)	1 (ref)
	Negative	244 (14.48)	2.31 (1.65 to 3.23)	> 0.001
Progesterone receptor	Positive	1237 (73.41)	1 (ref)
	Negative	401 (23.80)	2.13 (1.58 to 2.87)	> 0.001
Her2	Negative	1250 (74.18)	1 (ref)
	Positive	294 (17.45)	0.79 (0.55 to 1.14)	0.209
Intrinsic subtype	Luminal A	997 (59.17)	1 (ref)
	Luminal B	331 (19.64)	1.16 (0.81 to 1.66)	0.429
	Her2	81 (4.81)	1.50 (0.87 to 2.59)	0.143
	Basal-like	130 (7.72)	3.50 (2.31 to 5.30)	> 0.001
	Luminal ONI	91 (5.40)	0.20 (0.05 to 0.82)	0.026
Grade	I: Well differentiated	329 (19.53)	1 (ref)
	II: Moderately differentiated	520 (30.86)	1.48 (0.86 to 2.54)	0.157
	III: Bad differentiated	355 (21.07)	2.42 (1.41 to 4.17)	0.001
	missing	481 (28.55)	2.31 (1.27 to 4.18)	0.006

Hazard ratios and 95% confidence intervals estimated via Weibull regression

*Hazard ratios adjusted for age, hospital, stage and grade

ONI otherwise not identified