Table 4.

First-line treatment and their association with survival

Variable	Category	N (%)	Hazard ratio (95% CI) *	p
Surgery	Conservative	1231 (73.06)	1 (ref)
	Mastectomy	454 (26.94)	0.83 (0.56 to 1.22)	0.339
Surgical margins	Negative	1104 (65.52)	1 (ref)
	Positive	244 (14.48)	0.84 (0.50 to 1.42)	0.518
	Missing	337 (20.00)	1.03 (0.67 to 1.56)	0.905
Chemotherapy	No	817 (48.49)	1 (ref)
	Neoadjuvant	180 (10.68)	1.18 (0.72 to 1.91)	0.514
	Adjuvant	663 (39.35)	0.60 (0.40 to 0.89)	0.010
	Palliative	25 (1.48)	8.44 (4.61 to 15.4)	< 0.001
Radiotherapy	No	334 (22.45)	1 (ref)
	Neoadjuvant	5 (0.34)	6.05 (1.88 to 19.5)	0.003
	Adjuvant	1128 (75.81)	0.44 (0.30 to 0.65)	< 0.001
	Palliative	21 (1.41)	5.31 (2.57 to 11.0)	< 0.001
Immunotherapy	No	1498 (88.90)	1 (ref)
	Neoadjuvant	27 (1.60)	1.79 (0.87 to 3.67)	0.113
	Adjuvant	144 (8.55)	0.83 (0.48 to 1.44)	0.518
	Palliative	16 (0.95)	5.22 (2.57 to 10.6)	< 0.001
Endocrine therapy	No	662 (39.29)	1 (ref)
	Neoadjuvant	19 (1.13)	1.17 (0.50 to 2.76)	0.719
	Adjuvant	985 (58.46)	0.51 (0.37 to 0.71)	< 0.001
	Palliative	19 (1.13)	2.18 (1.05 to 4.56)	0.037

Hazard ratios and 95% confidence intervals estimated via Weibull regression

*Hazard ratios adjusted for age, hospital, stage and grade