Table 6.
Association between MX1 mRNA expression and clinicopathological parameters in the METABRIC (n = 1980)
| Clinicopathological parameters | METABRIC cohort | χ2 (p-value) | |
|---|---|---|---|
| Low (N = 990) | High (N = 990) | ||
| N (%) | N (%) | ||
| Age (years) | |||
| < 50 | 183 (43) | 241 (57) | 10.096 (0.001) |
| ≥ 50 | 807 (52) | 749 (48) | |
| Menopausal status | |||
| Pre-menopausal | 189 (43) | 247 (57) | 10.138 (0.001) |
| Post-menopausal | 797 (52) | 736 (48) | |
| Tumour size (cm) | |||
| < 2 | 330 (53) | 292 (47) | 3.177 (0.075) |
| ≥ 2 | 652 (49) | 686 (51) | |
| Tumour grade | |||
| Low | 118 (69) | 52 (31) | 103.008 (< 0.0001) |
| Moderate | 453 (59) | 317 (41) | |
| High | 363 (38) | 589 (62) | |
| Lymph-vascular invasion | |||
| Negative | 481 (52) | 449 (48) | 5.244 (0.022) |
| Positive | 291 (46) | 344 (54) | |
| Nodal status | |||
| Negative | 544 (53) | 491 (47) | 5.596 (0.018) |
| Positive | 443 (47) | 495 (53) | |
| Oestrogen receptor | |||
| Negative | 170 (36) | 304 (64) | 49.805 (< 0.0001) |
| Positive | 820 (54) | 686 (46) | |
| Progesterone receptor | |||
| Negative | 395 (42) | 545 (58) | 45.571 (< 0.0001) |
| Positive | 595 (57) | 445 (43) | |
| HER2 status | |||
| Negative | 880 (51) | 853 (49) | 3.372 (0.066) |
| Positive | 110 (44) | 137 (56) | |
| Intrinsic molecular classes | |||
| Luminal A | 452 (63) | 266 (37) | 140.785 (< 0.0001) |
| Luminal B | 223 (46) | 265 (54) | |
| HER2 enriched | 111 (46) | 129 (54) | |
| Basal like | 83 (25) | 246 (75) | |
| Normal like | 118 (59) | 81 (41) |
Significant p values are in bold