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. 2020 Mar 18;98(5):659–671. doi: 10.1007/s00109-020-01894-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Enhanced Ca²⁺ signaling in primary renal tubular epithelial cells from PKD−/− mice. a–c Original recordings and summaries of basal Ca²⁺ and ATP (100 μM) induced Ca²⁺ increase (Fura2) in primary renal epithelial cells isolated from wild type mice (PKD^fl/fl) and from mice with a renal tubular knockout of PKD1 (PKD^fl/fl-KspCre). d, e Original recordings and summaries of Ca²⁺ increase induced by inhibition of SERCA with CPA (10 μM). Store release and store-operated Ca²⁺ influx (SOCE) was augmented in PKD^−/− cells. Mean ± SEM (number of cells measured). ^#Significant difference when compared to wt (p < 0.05; ANOVA)