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. 2020 May 13;10:148. doi: 10.1038/s41398-020-0818-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Plasma CRP levels before and after placebo/minocycline administration expressed as a percentage change of before. Results are presented as mean + S.E.M. b Scores plot of the OPLS-DA model separating samples by treatment group. c Accuracy of the Minocycline/Placebo models were significantly better than that of the ensemble of randomly permuted models. d Representative images showing that differences in lipoprotein peaks were the key variables for building the OPLS-DA models. Spectra expressed as average of treatment group. Boxplot hinges depict 1st quartile to median (lower) and median to 3rd quartile (upper). *p < 0.05; ***p < 0.001.