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. 2020 May 13;10:7928. doi: 10.1038/s41598-020-64916-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The levels of glucose, insulin and IL-6 in blood of Ffar2-inhibited diabetic mice. STZ-induced diabetic mice were given GLPG-0974 (GLPG) once a week. Right after GLPG-0974 treatment, mice were fed with water (H₂O) or L. mesenteroides EH-1 (LM) once a day for 2 weeks. DMSO (0.1% in saline) was used as a vehicle control. The (a) glucose (blue, DMSO + H₂O; black, DMSO + L. mesenteroides EH-1; brown, GLPG + H₂O; red, GLPG + L. mesenteroides EH-1), (b) insulin and (c) IL-6 in fasting blood were detected. Data are the mean ± SD from 3 independent experiments with 4 mice per group. **p < 0.01; ***p < 0.001 vs water treatment.