Figure 2.

In vivo evaluation of worm burden and pathology in Sting^−/− mice. C57BL/6 (WT) and Sting^−/− mice (n = 10) were infected with 100 S. mansoni cercariae and, after 40 days of infection, the total number of worms recovered (a), number of eggs per gram of liver (b), number of granulomas per cm² (c) and area of granulomas in mm² (n = 10) (d) were evaluated. (**) and (***) are used to demonstrate statistical differences at p < 0.01 or p < 0.001 compared to the WT mice, respectively. For single comparisons, unpaired Student’s t-test was used.