Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 May 13;10:7907. doi: 10.1038/s41598-020-64431-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Validation of 23 secreted proteins in RA-SF and corresponding sera indicate their predominant production in the joint. (A and B) Inflammatory response molecules that differentiated RA-SF from OA-SF (exception: CCL2), and RA-serum from HD-serum. These proteins were elevated in RA-SF when compared to RA-serum (exception: LBP) and obviously diluted and/or neutralised in sera. (C and D) Inflammatory molecules that differentiated RA-SF from OA-SF and showed moderate or no dilution in sera. Protein concentrations were measured in paired samples of synovial fluid (SF) and serum from RA (n = 18) and OA (n = 15) patients as well as in serum from healthy donors (HD; n = 14). RA-SF: red; OA-SF: green; RA-serum: light red; OA-serum: light green, HD (healthy donors: grey).