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. 2020 May 13;8:20. doi: 10.1038/s41413-020-0096-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — OB differentiation downregulates the expression of neurotrophic factors and upregulates the expression of axonal repulsive cues. a Gene expression analysis of NGF, BDNF, and NT-3. Values normalized to the values of undifferentiated MSC (horizontal dashed line). b ELISA analysis of NGF, BDNF, and NT-3 in the conditioned medium of OB at different stages of differentiation. c Fold-change variation in the gene expression of the selected axonal repulsive cues throughout OB differentiation. Values normalized to the values of undifferentiated MSC. Red lines depict the proteins that downregulated or showed no significant changes. Green lines depict the proteins that upregulated. d ELISA analysis of Shh, Sema3A, and Wnt4 in the conditioned medium of OB at different stages of differentiation. *P < 0.05; **P < 0.01; ***P < 0.001